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NUANCE: Nanoscale Characterization Experimental Center

SPID Facility

"Bubbles" by Brendan Kerwin
"Bubbles" : by Brendan Kerwin / Created on the Bruker Dimension Icon Atomic Force Microscope


SPID was created to drive interdisciplinary research bridging the gap between hard nanostructures, soft materials, biological sciences, quantitative mechanical and electrical analysis and nanopatterning. SPID provides a wide range of imaging instrumentation and support facilities for atomic to molecular imaging. It supports a broad range of nanoscale science and technology characterization needs at nanoscale by providing state-of-the-art resources coupled with expert staff. Research at SPID encompasses physical and chemical sciences, engineering and life sciences, and has a strong inter-disciplinary emphasis. Every week, several new users coming from NU campuses, academia, industry, and government laboratories learn to use tools available in the center to carry out their research projects.

SPID Highlight

Development of ultrasound bioprobe for biological imaging

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(A) AFM topographical image of the ECs altered by the addition of thrombin. (B) Ultrasound bioprobe phase image showing notable contrast from intracellular fibers. Intracellular fibers are predominantly seen in the ultrasound phase image along with stretched gaps and subcellular phase contrast in the nuclear region of the cells.