Electron ptychography combined with 4D-STEM has emerged as a transformative technique for high-resolution phase imaging, offering sub-angstrom spatial resolution and nanometer-scale depth resolution for materials, alongside highly dose-efficient contrast for biological specimens. In this talk, I will cover the fundamental capabilities of modern electron ptychography and demonstrate how to overcome its traditional computational bottlenecks. I will introduce a streamlined, open-source workflow using py4DGUI and fast-acbf to achieve near-real-time feedback via GPU-based direct ptychography. Additionally, I will showcase PtyRAD, a GPU-accelerated framework that enables 20x faster iterative reconstructions. By highlighting real-world applications across both the physical and life sciences, I hope to empower researchers to confidently apply these open-source tools and unlock the full potential of their 4D-STEM data.